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The Arizona Cardinals will take on the Detroit Lions at 4:25 p.m. ET on Sunday at State Farm Stadium. The Cardinals are 2-0 and Detroit is 0-2. Arizona is favored by 5.5 points in the latest Cardinals vs. Lions odds from William Hill, and the over-under is set at 55.5. Before entering any Lions vs. Cardinals picks, you’ll want to see the NFL predictions from the model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,300 for $100 players on its top-rated NFL picks since its inception five-plus years ago. It’s off to a strong 5-2 roll on top-rated NFL picks this season. The model enters Week 3 on an incredible 101-67 roll on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL

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